Interstate '76 was probably the most easily hacked game I've ever seen. My best friend from HS and I messed around with hacking it for a few weeks before getting bored with it.
In that game, you had all your normal weapons like machine guns, missile launchers, flame throwers, and so on and so forth, but you also had a handheld .45 that you aimed out the window if you shifted your view to the driver's side window. The purpose of this was that if you got another car down to almost dead (health bar in the red), you could shoot them with the handgun and it would kill the driver without blowing up the car, otherwise it did no damage at all. This was pretty tricky to pull off because you had to continue driving your car while, you know, looking to the side rather than ahead. This was useful in singleplayer because you got more loot from cars you didn't fully destroy versus those you did. I don't recall if it had any use in multiplayer outside of bragging rights or extra points or whatever the goal was in multiplayer.
As far as hacking goes, with I'76, all you had to do was go into config files (pure text, no attempt at trying to encrypt anything at all by the devs) for the weapons, and replace the info for every weapon with the info for the .45 handgun. This meant that every single weapon now shot the .45 bullets, even the missile launchers and flame throwers and such. However, in multiplayer, doing this
only affected
you, client-side. Anyone else using unmodified config files still saw the normal weapons. This meant that they could be coming at you blasting you with a full suite of flamethrowers (which typically killed a car dead in a few seconds flat, if you got them lined up right), and on your end, all you would be seeing was a bunch of harmless bullets flying at you. On their end, they would be seeing your car being hit with flames but nothing happening at all, as if your car was invincible. Conversely, you could arm your car with the biggest, deadliest weapons in the game and use them on other players, in which case you'd just see yourself firing what looked like harmless bullets, and then their car would explode. Damage was always calculated client-side, you see. It was busted as shit.
Anyway, my friend and I tried this a time or two in "real" games, and after an initial bit of "hey, cool, it actually works," it made us feel bad to be fucking up peoples' games like that (I've
never been into the whole "ruining someone's game 'for teh lulz'" horseshit, because I've been on the receiving end too many times), so after that we mostly just puttered around in games tagged as "hackers only." Occasionally, some non-hackers would enter those games to futilely try to "get revenge" or whatever, but for the most part it just turned the game into a glorified IRC room, which was okay for how we were using it.
Honestly (and this is getting a bit off topic), the most fun I ever had playing I'76 with my friend and others was when we all played a game we called "death from above," in which we'd go into this one level that had a really high mountain with a flat plateau on the top of it. We'd take turns driving up to the top of this mountain while everyone else stayed at the bottom. Then, whoever was at the top would target someone on the ground and then drive full speed off the mountain top, trying to aim to crash the car into those on the ground. With the cinematic cameras available in the game, it was pretty cool, at least for a little while.