When they started talking about the Grand Theft Auto VI hacker around 6 minutes in, that was probably about as serious as I've ever heard Pat and Woolie get (relatively speaking), for a span of 20 minutes or so. Pat was really putting that psychology major and sociology minor to good use there (I say, only maybe half facetiously).
And then they set that topic aside and resumed just shitting all over the modern video game industry in general, in that sort of "you gotta laugh and joke about this stuff because it would be incredibly depressing otherwise" way that they do. Seriously, the likelihood of me ever buying another so-called AAA video game becomes ever tinier with every passing year, especially if the industry really is thinking about doing that "sell half games for twice the price" horseshit (or even just the more likely "raise prices to $100 USD by 2027" bullshit) that Pat and Woolie are talking about here.