This is one of my favorite point-and-click games, and certainly one of my favorite Star Trek games. The only Star Trek games I'd rate a bit higher are Star Trek: Judgment Rites, which is the sequel to the PC 25th Anniversary game shown here, and Star Trek: The Next Generation – A Final Unity, which they also briefly mention in the above video. Why there aren't more (and more modern) Star Trek games like these now, today, instead of the putrid turds we've gotten lately, I don't know.
You can find both of these Original Series games on Steam and on GOG. Sadly and frustratingly, A Final Unity isn't available on those platforms (yet, anyway).
And, yes, the PC version of 25th Anniversary is indeed many orders of magnitude better than the NES version, which is, itself, much better than the Game Boy version (even if that was the first Star Trek game I ever owned and played and for which I still have fairly fond memories, even though, in retrospect, it objectively sucked complete asshole).
Happy 50th anniversary, Star Trek. Here's to another successful 50 years (and hopefully much better video games in that time).